FIGURE 4.

OB and HPC from old mice exhibit lower DNA damage repair signals, but higher DNA damage markers. (a–c) Immunoblots of the indicated proteins PAR, 53BP1, ATM, XRCC1, PARP1, P21, Ƴ‐H2AX and β‐actin from OB (a), HPC (b) and PFC (c). Quantification of data is shown in Figures S6B–D and S7A–C. (d–f) Immunoblots of the indicated proteins cGAS, STING and β‐actin from OB (d), HPC (e) and PFC (f). Quantification of data is shown in Figure S7D. For all blots N = 3 mice per group, including 1 female and 2 males.