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. 2023 Feb 27;22(4):e13793. doi: 10.1111/acel.13793

FIGURE 6.

FIGURE 6

NR treatment increases lifespan and olfactory functions of old wild type mice. (a) Relative NAD+ level in OB tissue. N = 4–5 mice per group. One‐way ANOVA followed by Tukey's multiple comparisons test was applied for statistical analysis. (b) Lifespan of mice with/without NR supplementation. N = 20 mice per group, all males. p‐values compared with vehicle calculated using log‐rank test. (c) Time to start digging and grasp the food and in the buried food test. Unpaired t test was applied. N = 8–13 mice per group, all males. (d) Immunoblots of the indicated proteins cGAS, STING and β‐actin from OB. N = 3 mice per group, all males. Quantification of data is shown in Figure S9D. Values are mean and SEM. *p < 0.05; **p < 0.01; ***p<0.001.