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. 2023 Feb 27;15(4):e17450. doi: 10.15252/emmm.202317450

Figure 1. Metabolic disorders in POI patients.

Figure 1

  1. Clinical information of the cohort.
  2. PCA of serum metabolomics. Circles indicate 95% confidence intervals. N = 18.
  3. Heatmap showing the relative abundance of the top 75 differential expressed metabolites. N = 18.
  4. The relative abundance of valine (Val) and leucine‐isoleucine (Leu‐Ile). N = 18; Boxplot, central band stands for median, boxes stand for 50% of the data, and whiskers stand for min or max of the data.
  5. The relative abundance of 3‐hydroxybutyrate (3‐HOB) and acetylcarnitine (AC). N = 18; Boxplot, central band stands for median, boxes stand for 50% of the data, and whiskers stand for min or max of the data.
  6. The concentration of FGF21 in serum. Control, N = 18; POI, N = 20; Boxplot, central band stands for median, boxes stand for 50% of the data, whiskers stand for min or max of the data.
  7. The concentration of GDF15 in serum. Control, N = 14; POI, N = 9; Boxplot, central band stands for median, boxes stand for 50% of the data, and whiskers stand for min or max of the data.

Data information: Error bars stand for SEM of biological repeats. The P‐value was calculated by a two‐tailed t‐test with 2‐way ANOVA correction.

Source data are available online for this figure.