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. 2023 Feb 27;15(4):e17450. doi: 10.15252/emmm.202317450

Figure EV1. Metabolic details of POI patients.

Figure EV1

  • A
    Volcano plot showing the fold‐change and P‐value of metabolites. N = 18.
  • B
    Enrichment score and P‐value of metabolites downregulated in POI patients. N = 18.
  • C
    Relative abundance of valine (Val), acetyl‐carnitine (AC) but not leucine‐isoleucine (Leu‐Ile) in the serum of the Shandong Cohort. N = 10; Truncated violin plot, central band stands for median, and dotted lines stand for the upper quartile or the lower quartile of the data.
  • D
    The correlations between metabolites/FGF21 and clinical parameters. The P and r were calculated by the nonparametric Spearman test. N = 56.
  • E, F
    The concentration of FGF21 in mouse serum. (E) N = 5; (F) Control N = 10; Ketogenic diet, N = 6.
  • G, H
    The concentration of FSH in mouse serum. (G) Control, N = 7; Fgf21 OE, N = 6; and (H) control, N = 10; Ketogenic diet, N = 6.

Data information: Error bars stand for SEM. The P‐value was calculated by a two‐tailed t‐test with 2‐way ANOVA correction.

Source data are available online for this figure.