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. 2023 Feb 27;15(4):e17450. doi: 10.15252/emmm.202317450

Figure 3. Elevation of ceramide impaired granulosa cell function.

Figure 3

  • A, B
    Elevation of serum ceramide in POI patients from the Fudan Cohort or the Shandong Cohort. Left, the relative abundance of total ceramide; right, the relative abundance of ceramide with specific acyl chain. (A) N = 18; (B) N = 10; Truncated violin plot, central band stands for median, and dotted lines stand for the upper quartile or the lower quartile of the data.
  • C
    Heatmap showing the top 75 changed lipids in the serum of mice on a low BCAA diet. N = 10.
  • D
    Elevation of ceramide in the ovaries of mice on a low BCAA diet. N = 10; Truncated violin plot, central band stands for median, and dotted lines stand for the upper quartile or the lower quartile of the data.
  • E
    Decreases of E2 secretions from KGN cells treated with ceramide. N = 3.
  • F
    The serum concentration of FSH in mice with ceramide treatment. N = 7.
  • G
    Number of pups from mice with ceramide treatment. Control, N = 4; ceramide treatment, N = 5.
  • H
    The changes in follicle count from mice with ceramide treatment. N = 7.

Data information: S1, Primordial; S2, Primary; S3, Secondary; S4, Antral; S5, Atretic. Error bars stand for SEM of biological repeats. The P‐value was calculated by a two‐tailed t‐test with 2‐way ANOVA correction.

Source data are available online for this figure.