TABLE 2.
Primary and secondary outcomes for the study groups
| Short antibiotic course (n=24) | Long antibiotic course (n=24) | p-value | |||
| Participants with available data | Result | Participant with available data | Result | ||
| Treatment failure | |||||
| ITT population | 24 | 4 (16.7) | 24 | 3 (12.5) | χ2=0.167 (p=0.683), Fisher's exact p=1 |
| PP population | 20 | 4 (20) | 24 | 3 (12.5) | χ2=0.459 (p=0.498), Fisher's exact p=0.684 |
| Total antibiotic duration, days | 24 | 20.5 (18–22.5) | 24 | 34.5 (32–38) | <0.001 |
| Returned to ADL | 20 | 11 (55) | 21 | 9 (42.9) | 0.436 |
| Time to return to ADL from admission, days | 11 | 10 (4.5–18) | 9 | 13 (6–18) | 0.970 |
| Antibiotic-related adverse events | 21 | 0 (0) | 24 | 2 (8.3) | Fisher's exact p=0.488 |
| Residual pleural collection | 20 | 4 (20) | 21 | 2 (9.5) | Fisher exact p=0.409 |
| Persistent symptoms at 6 weeks post-admission | 20 | 9 (45) | 21 | 11 (52.4) | χ2=0.382 (p=0.537) |
Data are presented as n, n (%) or median (interquartile range), unless otherwise stated. ADL: activities of daily living; ITT: intention-to-treat; PP: per-protocol.