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. 2023 Mar 5;19(5):1543–1563. doi: 10.7150/ijbs.77133

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FMR1 promotes PCa aggressiveness and relates to a poor prognosis in PCa. (A) WB confirms the transfection efficiency of siRNA targeting FMR1 in 22Rv1 and DU145 cell lines. (B) CCK-8 assays demonstrate the proliferation changes after FMR1 downregulation in 22Rv1 and DU145 cell lines. (C) Plate colony formation assays exhibit FMR1-silenced PCa cells' ability to form colonies. (D) Transwell experiments determine invasiveness differences in FMR1-silenced PCa cells with si-NC as a negative control. (E) KM survival analysis validated FMR1's prognostic value in PCa.