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. 2023 Mar 5;19(5):1543–1563. doi: 10.7150/ijbs.77133

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Downregulating FMR1 impairs circRBM33-mediated aggressive phenotypes in PCa cells. (A) WB validates the influence of FMR1 knockdown on PDHA expression in circRBM33-overexpressed cells (22Rv1 and C4-2). (B) The CCK-8 assay examines the influence of FMR1 silencing on cell growth in circRBM33-overexpressed cells. (C) The influence of FMR1 downregulation on colony formation ability was examined in circRBM33-overexpressed cells. (D) The Transwell assay determines the impact of FMR1 silencing on invasiveness in circRBM33-overexpressed cells. (E) Detection of the NAD⁺/NADH ratio changes in the circRBM33-overexpressed cells when FMR1 is downregulated. (F-G) Detection of ATP and acetyl-CoA production changes in circRBM33-overexpressed cells when FMR1 is downregulated. (H) Seahorse experiments detects the basal and maximal OCR in the circRBM33-overexpressed cells when FMR1 was downregulated.