Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Feb 21;19(5):1352–1368. doi: 10.7150/ijbs.79022

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The author(s)

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

PMC Copyright notice

Gastric cancer cells educate neutrophils via TGFβ1. (A) TGFBRAP1 expression was increased in Edu-Neus (P = 0.000). (B) TGFβ1 mRNA level in tumor tissues was positively associated with TNM staging (P = 0.004) and overall survival negatively (C) (P = 0.022). (D) TGFβ1 mRNA level was correlated with FAM3C level in gastric cancer (P = 0.002). (E) Exogenous TGFβ1 up-regulated FAM3C expression in neutrophils in a dose-dependent manner, and the expressions of p-Smad2, p-Smad3 or p-Smad2/3 were up-regulated concurrently. (F) Treatment with TGFβ1 inhibitor, Disitertide, or TGFβ1 receptor (TGFβ1R) inhibitor, LY-364947, inhibited FAM3C expression. (G) Treatment with Disitertide or LY-364947 reversed expression of EMT markers in tumor cells. (H) LY-364947 down-regulated FAM3C and p-Smad2 or p-Smad3 expression in neutrophils simultaneously. (Neu, neutrophil; Edu-Neu, tumor-educated neutrophil)