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Inhibitory effects of TGI/HA-CS double network hydrogel on ECM degradation.
(A) Gene expression of ECM-degrading enzymes in MMP or ADAMTS family, inflammatory factors (IL-1β and TNF-ɑ) and inflammation-related enzymes (iNOS and COX-2) in chondrocytes under inflammatory conditions. (B) Immunofluorescence of MMP-9 and ADAMTS-5, bar = 100 μm. Quntification of (C) MMP-9, (D) ADAMTS-5 and (E) IL-6. *p < 0.05, **p < 0.01, ***p < 0.001.
