TABLE 1.
MRI acquisition | Applied and optimized | Protocolled experiments | Summary results |
---|---|---|---|
T2‐weighted imaging |
Porcine n = 22 Human n = 4 |
Induced ischemia‐reperfusion (duration 30–90 min) Porcine n = 6 Iron oxide labeled MSCs Porcine n = 1 |
During ischemia, the T2 signal notably decreased and after reperfusion, it took up to 30 min for this signal to recover to its initial value. MSCs were inhomogeneously deposited within the renal cortex |
T2* map |
Porcine n = 22 Human n = 4 |
Deoxygenation 20 min Porcine n = 1 |
Baseline: T2* = 50.4 ms 5 min stop O2: T2* = 46.2 ms 10 min stop O2: T2* = 47.8 ms 20 min stop O2: T2* = 27.8 ms 5 min restart O2: T2* = 45.3 ms |
ASL | Porcine n = 13 |
Perfusion maps first 3 h Porcine n = 9 Human n = 4 |
Corticomedullar ratio at 30, 60, 120, and 180 min Porcine: 2.1, 5.0, 6.5 and 5.3 Human: 1.2, 3.0, 4.5 and 6.6 |
Spectroscopy | n.a. |
Hyperpolarized [1‐13C]pyruvate Porcine n = 4 |
13C‐lactate concentrations were decreased in the cortex compared with the medullar regions |
Abbreviations: ASL, arterial spin labeling; MRI, magnetic resonance imaging; MSCs, mesenchymal stromal cells.