TABLE 3.
Univariate analysis to identify factors associated with survival after lung transplantation
| Univariate | |||||
|---|---|---|---|---|---|
| Reference | Modality | HR | 95%CI | p‐value | |
| Sex | Male | Female | 0.74 | 0.29–1.91 | .53 |
| Age at transplantation | Continuous | 1.00 | 0.95–1.04 | .85 | |
| Body mass index at listing | Continuous | 0.95 | 0.81–1.11 | .50 | |
| Caucasian | No | Yes | 0.73 | 0.26–2.07 | .56 |
| Smoking history | No | Yes | 1.44 | 0.55–3.81 | .46 |
| CMV: donor positive / recipient negative | No | Yes | 1.17 | 0.43–3.18 | .76 |
| Blood group | O | A | 3.25 | 0.40–26.46 | .27 |
| B | 2.07 | 0.19–22.95 | .55 | ||
| AB | 2.72 | 0.17–43.59 | .48 | ||
| Lung transplant procedure | Double | Single | 0.74 | 0.17–3.24 | .69 |
| High‐priority transplant allocation program | No | Yes | 1.88 | 0.74–4.79 | .18 |
| Pulmonary hypertension | No | Yes | 1.17 | 0.25–5.53 | .84 |
| Severe pulmonary hypertension | No | Yes | 1.41 | 0.20–3.08 | .74 |
| Cardiopulmonary bypass | No | Yes | 0.60 | 0.23–1.56 | .30 |
| Induction | No | Yes | 0.63 | 0.23–1.68 | .35 |
| Dialysis during intensive unit stay | No | Yes | 3.05 | 1.14–8.21 | .03 |
| Primary graft dysfunction Grade 3 at 72 h | No | Yes | 2.47 | 0.93–6.61 | .07 |
| Ventilation time during intensive care unit stay | No | Yes | 0.99 | 0.97–1.01 | .48 |
| Hemothorax | No | Yes | 0.19 | 0.03–1.45 | .11 |
| Pneumonia | No | Yes | 0.99 | 0.97–1.01 | .48 |
| Preformed donor‐specific antibody | No | Yes | 1.41 | 0.46–4.29 | .55 |
| c‐IIM | No | Yes | 4.88 | 1.41–16.90 | .01 |
| Rapidly progressive interstitial lung disease | No | Yes | 1.94 | 0.76–4.90 | .16 |
| Skin involvement | No | Yes | 3.33 | 1.30–8.52 | .01 |
| Raynaud's phenomenon | No | Yes | 1.01 | 0.36–2.84 | .99 |
| Esophageal dysmotility | No | Yes | 3.05 | 0.68–13.69 | .14 |
| Gastroesophageal reflux disease | No | Yes | 1.60 | 0.62–4.16 | .33 |
| Swallowing impairment | No | Yes | 1.60 | 0.46–5.54 | .46 |
| Number of immunosuppressive lines before transplantation | Continuous variable | 1.36 | 0.99–1.87 | .06 | |
| 6‐min walk test | Continuous variable | 1.00 | 0.99–1.00 | .67 | |
| Forced vital capacity | Continuous variable | 0.98 | 0.94–1.02 | .31 | |
| Forced expired volume in 1 s | Continuous variable | 0.98 | 0.94–1.03 | .49 | |
| Forced expired volume in 1 s/Forced vital capacity | Continuous variable | 1.03 | 0.98–1.08 | .22 | |
| Total lung capacity | Continuous variable | 0.97 | 0.93–1.02 | .24 | |
| Diffusing capacity for carbon monoxide | Continuous variable | 1.01 | 0.96–1.06 | .78 | |
| Right atrial pressure | Continuous variable | 1.02 | 0.95–1.09 | .56 | |
| Mean pulmonary artery pressure | Continuous variable | 1.00 | 0.95–1.05 | .90 | |
| Pulmonary capillary wedge pressure | Continuous variable | 1.26 | 1.00–1.60 | .16 | |
| Cardiac index | Continuous variable | 0.56 | 0.20–1.55 | .26 | |
| Pulmonary vascular resistance | Continuous variable | 0.86 | 0.56–1.32 | .47 | |
| Predominant pattern on thoracic high‐resolution computed tomography | Nonspecific interstitial pneumonia | Usual interstitial pneumonia | 2.05 | 0.73–5.79 | .17 |
| Organizing pneumonia | 2.17 | 0.46–10.12 | .32 | ||
Abbreviations: 95%CI, 95% confidence interval; c‐IIM, classical idiopathic inflammatory myositis; CMV, cytomegalovirus; HR, hazard ratio.