TABLE 1.

Trazodone and gabapentin population PK parameter estimates in mice

Parameter	Units	Estimate	%CV or RSV%	%SE	Parameter	Units	Estimate	%CV or RSV%	%SE
(a) Trazodone					(b) Gabapentin
k	h−1	1.25	–	4.48	k	h−1	0.112	–	58.8
V 1/F	L/kg	5.95	–	6.30	V 1/F	L/kg	0.846	–	4.65
k 12	h−1	0.982	–	19.8	k 12	h−1	0.935	–	17.8
k 21	h−1	1.51	–	19.9	k 21	h−1	0.110	–	15.2
D 1	h	0.0833	–	–	D 1	h	0.167	–	–
Inter‐individual variability
${\overline{\omega }}_v^2$		0.0526	22.9	59.9	${\overline{\omega }}_v^2$		0.00287	5.36	>100
${\overline{\omega }}_k^2$		0.00899	9.48	192	${\overline{\omega }}_k^2$		0.337	58.1	>100
${\overline{\omega }}_{k12}^2$		0.577	76.0	29.6	${\overline{\omega }}_{k12}^2$		1.43	120	35
Intra‐individual variability
${\sigma }_{\text{prop}}^2$		0.0752	27.4	37.8	${\sigma }_{\text{prop}}^2$		0.0598	24.5	>100

Note: Population PK parameters were estimated in mice using data of trazodone administered at 1, 3, and 10 mg/kg (panel a) and gabapentin administered at 10, 30, and 100 mg/kg (panel b).

Abbreviation: %CV, percent coefficient of variation; %SE, percent standard error; D ₁, duration of the zero‐order absorption; k: elimination rate constant; k ₁₂, k ₂₁, intercompartment rate constants; V ₁/F, volume of distribution of the central compartment; ω, interindividual variability; σ, intra‐individual variability.