TABLE 6.

Translation of PD results to humans

		Gabapentin
		0 mg	50 mg	100 mg	200 mg	400 mg	800 mg
Trazodone (mg)
0	Mean	–	5.4	10.6	16.4	22.2	28.2
	Median	–	2.51	5.75	10.13	15.5	22.6
	1st Q	–	1.05	2.28	4.13	6.5	9.9
	3rd Q	–	6.43	14.0	23.2	32.7	42.4
0.5	Mean	4.93	21.7	30.0
	Median	2.76	17.9	26.2
	1st Q	1.18	13.2	20.8
	3rd Q	6.03	25.7	36.2
1.0	Mean	9.20	29.1	39.2
	Median	5.67	26.0	37.0
	1st Q	2.50	20.6	30.4
	3rd Q	11.75	33.9	45.7
5	Mean	27.6	58.2	69.4
	Median	21.7	57.76	68.8
	1st Q	10.5	51.18	64.7
	3rd Q	39.6	64.20	73.8
10	Mean	37.5	72.09	81.5
	Median	34.1	71.67	81.7
	1st Q	18.6	66.83	78.2
	3rd Q	53.3	71.67	81.7
25	Mean	56.2
	Median	58.7
	1st Q	38.4
	3rd Q	75.0
50	Mean	69.41
	Median	73.96
	1st Q	55.09
	3rd Q	85.97

Note: Simulation of percentage of inhibition of pain stimulus in humans after single oral ascending doses of trazodone and gabapentin administered alone or in combination. Bold values indicate the low dose combinations of the two compounds indicating enhanced effects when co‐administered.

Abbreviation: PD, pharmacodynamic.