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. 2023 Apr 10;6(6):e202302054. doi: 10.26508/lsa.202302054

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© 2023 Alagia et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

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Figure 6. — (A) Venn diagram showing an overlap between up-regulated protein-coding genes from vtRNA1-2 KO (compared with WT), vtRNA1-2 KO svtRNA1-2 predicted targets, and svtRNA1-2 predicted targets from up-regulated genes in AGO2 and Dicer KD cells (top). Tables showing names of 29 svtRNA1-2 target genes. Heatmap is showing fold of expression change for each target gene in vtRNA1-2 KO cells. (B) Pie chart showing cellular localisation of 29 svtRNA1-2 target genes. (C) STRING analysis showing interactions among 29 svtRNA1-2 target genes. Proteins involved in signalling are marked in blue, and glycoproteins are marked in green. (D) Pathway analysis showing an association of svtRNA1-2 target genes with negative regulation of cell adhesion. (E) Representative examples of bright-field microscopy showing differences in a cell adhesion phenotype in WT and vtRNA1-2 KO cells.