Fig. 7.

The evaluation of in-situ bone regeneration with various scaffolds implantation. (A) A schematic showing the establishment of 5-mm skull defect model of SD rats and the mechanism for enhanced bone regeneration via the promoted neurogenesis and angiogenesis. (B) Reconstructed 3D micro-CT images and corresponding thermal imaging analysis of rat skulls at 4 W and 8 W post-operation. (C, D) The quantitative evaluation on regenerated bone via BV/TV and BMD analysis. *denotes the significant difference between PCL, β-TCP, WH, and PWH scaffold groups. *P < 0.05, significant, **P < 0.01 and ***P < 0.001, highly significant (n = 4).