. 2022 Sep 27;131(1):20–31. doi: 10.1111/bju.15883

Table 2.

Summary of selected results from Postema et al. [6] and Lebastchi et al. [7].

Definition	Postema et al. [6]	Lebastchi et al. [7]
Study methodology	Three‐round Delphi method. The final round incorporated 73 responses (Urologists [75%], Radiologists [11%], Radiotherapists [4%], Researchers [4%], Pathologists [3%] and Medical Oncologists [3%]). The level of agreement necessary to achieve consensus was defined as >80% [5].	Three‐round Delphi method. The final round incorporated 48 responses (Urologists [72%] and Radiologists [28%]). The level of agreement necessary to achieve consensus was defined as >80% [6].
Main findings	Definitions: FT ‐ an anatomy‐based (zonal) treatment strategy (e.g., targeting a quadrant, a lobe or both lobes sub‐totally). Index lesion ‐ the single dominant lesion in terms of grade and size, where grade is more important. There can be only one index lesion. The term index lesion itself may be of limited use in the context of FT. It is more important to have an overview of all significant lesions that warrant treatment rather than a single defined index lesion. Ablation failure ‐ ablation failure is a failure of the technique to destroy the tissue in the treated zone, evidenced by tumour found within the treated zone. Ablation failure is just one of the causes that can lead to failure of FT as a whole. Other types of failure include targeting failure and selection failure. Must be confirmed by targeted biopsy. Selection failure ‐ FT was inappropriately indicated, evidenced by short‐term post‐treatment identification of metastatic or locally advanced disease. There is no agreement on whether significant PCa in short‐term biopsies taken inside or outside the treatment zone and the need for whole‐gland treatment during follow‐up constitute selection failure. Serious side‐effects ‐ Clavien–Dindo‐scale ≥III as ‘serious’ side‐effects	Definitions: FT ‐ guided ablation of an image‐defined, biopsy‐confirmed, cancerous lesion with a safety margin surrounding the targeted lesion. Partial gland ablation ‐ includes quadrant ablation, hemi‐ablation, hockey‐stick ablation, and subtotal ablation. Index lesion ‐ could not achieve consensus that an index lesion can be defined solely by being the largest lesion. Also, no consensus that GG1 cancers could be defined as index lesion.

Definition

Postema et al. [6]

Lebastchi et al. [7]

Study methodology

Three‐round Delphi method.

The final round incorporated 73 responses (Urologists [75%], Radiologists [11%], Radiotherapists [4%], Researchers [4%], Pathologists [3%] and Medical Oncologists [3%]). The level of agreement necessary to achieve consensus was defined as >80% [5].

Three‐round Delphi method.

The final round incorporated 48 responses (Urologists [72%] and Radiologists [28%]). The level of agreement necessary to achieve consensus was defined as >80% [6].

Main findings

Definitions:

FT ‐ an anatomy‐based (zonal) treatment strategy (e.g., targeting a quadrant, a lobe or both lobes sub‐totally).

Index lesion ‐ the single dominant lesion in terms of grade and size, where grade is more important. There can be only one index lesion. The term index lesion itself may be of limited use in the context of FT. It is more important to have an overview of all significant lesions that warrant treatment rather than a single defined index lesion.

Ablation failure ‐ ablation failure is a failure of the technique to destroy the tissue in the treated zone, evidenced by tumour found within the treated zone. Ablation failure is just one of the causes that can lead to failure of FT as a whole. Other types of failure include targeting failure and selection failure. Must be confirmed by targeted biopsy.

Selection failure ‐ FT was inappropriately indicated, evidenced by short‐term post‐treatment identification of metastatic or locally advanced disease. There is no agreement on whether significant PCa in short‐term biopsies taken inside or outside the treatment zone and the need for whole‐gland treatment during follow‐up constitute selection failure.

Serious side‐effects ‐ Clavien–Dindo‐scale ≥III as ‘serious’ side‐effects

Definitions:

FT ‐ guided ablation of an image‐defined, biopsy‐confirmed, cancerous lesion with a safety margin surrounding the targeted lesion.

Partial gland ablation ‐ includes quadrant ablation, hemi‐ablation, hockey‐stick ablation, and subtotal ablation.

Index lesion ‐ could not achieve consensus that an index lesion can be defined solely by being the largest lesion. Also, no consensus that GG1 cancers could be defined as index lesion.

GG1, Grade Group 1. The level of agreement necessary to achieve consensus was defined as >80%.