. Author manuscript; available in PMC: 2023 Apr 11.

Published in final edited form as: J Med Chem. 2021 May 19;64(11):7617–7629. doi: 10.1021/acs.jmedchem.1c00318

Table 3.

Cytotoxicity of C12 in Drug-Resistant MCF-7 Cells

	GI₅₀ ± SD^a (μM)

Cpd	MCF-7	MCF-7/TDP1	resistance index^b
CPT	0.35 ± 0.04	3.21 ± 0.17	9.2
TPT	0.35 ± 0.01	7.42 ± 0.24	21.2
NTD-96	0.20 ± 0.03	3.98 ± 0.9	19.9
C12	0.77 ± 0.10	2.59 ± 0.31	3.4

GI₅₀ values (mean ± SD) were defined as the concentrations of compounds that resulted in a 50% cell growth inhibition and obtained from an MTT assay. Every experiment was repeated at least three times.

The resistance index was calculated by dividing the GI₅₀ of MCF-7/TDP1 cells by the GI₅₀ of MCF-7 cells.