Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Sep 25;37(12):2243–2254. doi: 10.1111/jgh.15987

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 The Authors. Journal of Gastroenterology and Hepatology published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

PMC Copyright notice

PD‐L1‐EVs alleviated colitis induced by 5% DSS in rats and regulate the expression of PI3K/Akt/mTOR pathway. (a) Histopathological changes in colon tissues analyzed by hematoxylin and eosin (HE) staining. Original magnification, 100×. (b) Histopathological score of colon sections of rats in each group. (c) The body weight of the rats in each group. (d) Western blotting analysis of PD1, p‐PTEN, PD‐L1, p‐PI3K, p‐AKT, and p‐mTOR in colon tissue. GAPDH was used as a loading control. (e) The protein quantitative analysis of PD1, p‐PTEN, PD‐L1, p‐PI3K, p‐AKT and p‐mTOR in colon tissue.(##P < 0.01, DSS group vs Control group; *P < 0.05, **P < 0.01, each treatment group vs DSS group; ns: not statistically significant, △P < 0.05, △△P < 0.01, vs PD‐L1‐EVs+bpv group). (c) , Control; , bpv; , PD‐L1‐EVs; , PD‐L1‐EVs+bpv; , DSS [Color figure can be viewed at wileyonlinelibrary.com]

Inline graphic — PD‐L1‐EVs alleviated colitis induced by 5% DSS in rats and regulate the expression of PI3K/Akt/mTOR pathway. (a) Histopathological changes in colon tissues analyzed by hematoxylin and eosin (HE) staining. Original magnification, 100×. (b) Histopathological score of colon sections of rats in each group. (c) The body weight of the rats in each group. (d) Western blotting analysis of PD1, p‐PTEN, PD‐L1, p‐PI3K, p‐AKT, and p‐mTOR in colon tissue. GAPDH was used as a loading control. (e) The protein quantitative analysis of PD1, p‐PTEN, PD‐L1, p‐PI3K, p‐AKT and p‐mTOR in colon tissue.(##P < 0.01, DSS group vs Control group; *P < 0.05, **P < 0.01, each treatment group vs DSS group; ns: not statistically significant, △P < 0.05, △△P < 0.01, vs PD‐L1‐EVs+bpv group). (c) , Control; , bpv; , PD‐L1‐EVs; , PD‐L1‐EVs+bpv; , DSS [Color figure can be viewed at wileyonlinelibrary.com]