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. 2022 Aug 19;49(12):7672–7682. doi: 10.1002/mp.15911

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© 2022 The Authors. Medical Physics published by Wiley Periodicals LLC on behalf of American Association of Physicists in Medicine.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Break‐even normal tissue (NT) sparing factor W _BE as predicted by the linear‐quadratic (LQ) and LQ‐linear (LQ‐L) models as a function of dose per fraction d for relative dose levels r of 1.0 (a) and 0.5 (b). Curves for different combinations of (α/β)_NT‐ratios (2, 3, 5, and 10 Gy) and (α/β)_T‐ratios (5, 10, and 20 Gy) are displayed. A normofractionated treatment with $d = 2 Gy$ is indicated by a gray dashed vertical line.