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. 2022 Aug 6;95(1):e28036. doi: 10.1002/jmv.28036

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© 2022 The Authors. Journal of Medical Virology published by Wiley Periodicals LLC.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Genomic annotation of the MPXV‐2022 outbreak. (A) Illustration of previously identified MPXV protein annotations. Functions of homologous proteins are color‐coded. (B) A cumulative number of variants type greater than three times on the protein. All the protein annotations were colored accordingly, and the most variable proteins (top 10 percentile) were labeled. (C) A cumulative number of variants type 20 times more in the WA lineage at different sublineages. Genome composition changes were colored accordingly. (D) The identified protein sequence similarity between consensus outbreak sequences and other strains (MPXV‐UK‐P2, MPV‐ZAI, MVA‐BN, VAC‐COP, CPV‐GRI, and VAR‐IND).