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(a) Putative interactions between catechin and transient receptor potential M8 (TRPM8) (PDB: 6NR3). Free energy of binding (ΔG) and affinity (Ki) are −7.8 kcal/mol and 1.9 μM, respectively. (b) Putative interactions between WS12 and transient receptor potential M8 (TRPM8) (PDB: 6NR3). Free energy of binding (ΔG) and affinity (Ki) are −8.0 kcal/mol and 1.4 μM, respectively
