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. 2023 Mar 20;22(4):1092–1104. doi: 10.1021/acs.jproteome.2c00441

Figure 2.

Figure 2

Unified modeling language (UML) diagram of modeling- and contrast-related classes. Different strategies, e.g., lm, lmer, and glm (Table 2), reference methods to fit models, and compute contrasts. The model builder method fits the statistical model given the data and a strategy. The models are used to analyze variance (ANOVA) or to estimate contrasts. All classes estimating contrasts implement the ContrastsInterface. Results of external tools, e.g., SAINTexpress, or proDA are adapted to implement the Contrasts interface.