Table 3.
Association between HOXA9 gene promotor methylation, SOX2 gene, HV2 gene copy number variation and clinicopathological data
| No | HOXA9% methylation | Test of Sig | P | SOX2 CNV | Test of Sig | P | HV2 CNV | Test of Sig | P | |
|---|---|---|---|---|---|---|---|---|---|---|
| Median (Min. – Max.) | Median (Min. – Max.) | Median (Min. – Max.) | ||||||||
| Age (years) | (30.0 – 75.0) | rs = 0.389 | 0.055 | (30.0 – 75.0) | rs = -0.138 | 0.512 | (30.0 – 75.0) | rs = -0.025 | 0.907 | |
| Sex | ||||||||||
| Male | 23 | 13.0 (2.0 – 85.0) | U = 11.0 | 0.280 | 11.0 (0.0 – 19.0) | U = 12.50 | 0.327 | 1.0 (0.0 – 3.0) | U = 11.50 | 0.280 |
| Female | 2 | 3.50 (2.0 – 5.0) | 14.50 (12.0 – 17.0) | 2.0 (1.0 – 3.0) | ||||||
| Smoking | ||||||||||
| Non-smoker | 2 | 3.50 (2.0 – 5.0) | U = 11.00 | 0.280 | 14.50 (12.0 – 17.0) | U = 12.50 | 0.327 | 2.0 (1.0 – 3.0) | U = 11.50 | 0.280 |
| Smoker | 23 | 13.0 (2.0 – 85.0) | 11.0 (0.0 – 19.0) | 1.0 (0.0 – 3.0) | ||||||
| Pathology | ||||||||||
| SCC | 11 | 11.0 (2.0 – 85.0) | U = 73.00 | 0.851 | 5.0 (0.0 – 18.0) | U = 57.50 | 0.291 | 1.0 (0.0 – 3.0) | U = 74.0 | 0.893 |
| Adenocarcinoma | 14 | 10.0 (2.0 – 64.0) | 12.0 (1.0 – 19.0) | 1.0 (0.0 – 3.0) | ||||||
| Staging | ||||||||||
| I + II | 5 | 33.0 (2.0 – 41.0) | U = 37.50 | 0.408 | 5.0 (0.0 – 12.0) | U = 27.00 | 0.129 | 0.0 (0.0 – 3.0) | U = 37.50 | 0.408 |
| III + IV | 20 | 11.0 (2.0 – 85.0) | 12.50 (0.0 – 19.0) | 1.0 (0.0 – 3.0) | ||||||
U Mann Whitney test, p p value for comparing between different categories, rs Spearman coefficient