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. 2023 Apr 10;21:252. doi: 10.1186/s12967-023-04072-z

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Systemic inflammation across periodontal health conditions during exposure to MetS factors follows a sex-specific pattern. Panel A Stratified analysis of serum CRP levels across periodontal health conditions based on exposure. Panel B Sex-stratified analysis of serum CRP levels of exposed and non-exposed across periodontal health conditions. Panel C Sex-stratified analysis of serum CRP levels by presence and extent of gingival bleeding. Panel D Sex-stratified analysis of serum CRP levels by incremental MetS components. Panel E Sex-stratified analysis of PISA by incremental MetS components. Panel F Sex-specific correlation of PISA and CRP levels based on exposure. Panel G Heatmap of CRP levels on individuals with single MetS components across periodontal health conditions. Asterisk indicates significant different mean CRP levels compared to healthy controls. Wilcoxon test adjusted for multiple comparisons with Bonferroni correction. Ns: not significant; *p < 0.05; **p < 0.01; p < 0.001; p < 0.0001