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Schematic diagram represents the mechanism that inhibiting HMGB1 induces autophagy through lysosomal membrane permeabilization(LMP). Glycyrrhizin inhibiting the HMGB1 expression induces autophagy by restoration of lysosomal membrane integrity. Recovered lysosomal membrane reduces LMP along with enhanced autolysosome formation which ultimately degrades the intracellular H. pylori from its gastric niche
