Table 4.
Correlations between odor identification scores and mRNA and cognitive measures.
| Measure | Total sample | CSZ subjects | Control subjects |
|---|---|---|---|
| mRNA levels in lymphocytes | |||
| DNMT1 OR (lg) | r = −0.291 p = 0.026, n = 58 | r = −0.330 p = 0.087 n = 28 | r = −0.210 p = 0.266 n = 30 |
| DNMT1 CP | r = −0.603 p = 0.002, n = 24 | r = −0.688 p = 0.013 n = 12 | r = −0.688 p = 0.013 n = 12 |
| MATRICS cognitive measures | |||
| Speed of processing | r = 0.359 p < 0.001 n = 104 | r = 0.304 p = 0.022 n = 57 | r = 0.240 p = 0.104 n = 47 |
| Attention vigilance | r = 0.205 p = 0.039 n = 102 | r = 0.195 p = 0.153 n = 55 | r = −0.066 p = 0.660 n = 47 |
| Working memory | r = 0.291 p = 0.003 n = 104 | r = 0.273 p = 0.040 n = 57 | r = 0.057 p = 0.702 n = 47 |
| Verbal learning | r = 0.190 p = 0.053 n = 104 | r = 0.113 p = 0.402 n = 57 | r = 0.032 p = 0.829 n = 47 |
| Visual learning | r = 0.208 p = 0.034 n = 104 | r = 0.160 p = 0.235 n = 57 | r = 0.055 p = 0.713 n = 47 |
| Reasoning/Problem solving | r = 0.259 p = 0.008 n = 104 | r = 0.295 p = 0.026 n = 57 | r = 0.082 p = 0.583 n = 47 |
| Social cognition | r = 0.090 p = 0.364 n = 103 | r = −0.052 p = 0.703, n = 56 | r = −0.176 p = 0.236 n = 47 |
| Overall composite score | r = 0.315 p = 0.001 n = 102 | r = 0.300 p = 0.026 n = 55 | r = 0.061 p = 0.684 n = 47 |
r, Pearson correlation coefficient. GABAergic mRNAs showed no significant correlations with odor identification scores. lg is log10 transformation of DNMT1 values which was used in the analysis because it provided a more normalized distribution of values for this variable.