Table 5.
Correlations between odor discrimination scores and mRNA and cognitive measures.
| Measure | Total sample | CSZ subjects | Control subjects |
|---|---|---|---|
| mRNA levels in lymphocytes | |||
| GAD1(lg) | r = −0.392 p = 0.001, n = 65 | r = −0.380 p = 0.024 n = 35 | r = −0.081 p = 0.669 n = 30 |
| GAD25 (lg) | r = −0.350 p = 0.003, n = 68 | r = −0.424 p = 0.01 n = 36 | r = −0.094 p = 0.609 n = 32 |
| GAD67 | rho = −0.323 p = 0.007 n = 68 | rho = −0.408 p = 0.014 n = 36 | rho = −0.106 p = 0.565 n = 32 |
| MATRICS cognitive measures | |||
| Speed of processing | r = 0.419 p < 0.001 n = 104 | r = 0.223 p = 0.095 n = 57 | r = 0.142 p = 0.340 n = 47 |
| Attention vigilance | r = 0.373 p < 0.001 n = 102 | r = 0.217 p = 0.111 n = 55 | r = 0.135 p = 0.364 n = 47 |
| Working memory | r = 0.480 p < 0.001 n = 104 | r = 0.345 p = 0.009 n = 57 | r = 0.226 p = 0.127 n = 47 |
| Verbal learning | r = 0.421 p < 0.001 n = 104 | r = 0.300 p = 0.023 n = 57 | r = 0.147 p = 0.324 n = 47 |
| Visual learning | r = 0.282 p = 0.004 n = 104 | r = 0.166 p = 0.216 n = 57 | r = 0.012 p = 0.934 n = 47 |
| Reasoning/Problem solving | r = 0.261 p = 0.007 n = 104 | r = 0.127 p = 0.345 n = 57 | r = 0.099 p = 0.509 n = 47 |
| Social cognition | r = 0.273 p = 0.005 n = 103 | r = 0.101 p = 0.461 n = 56 | r = −0.036 p = 0.812 n = 47 |
| Overall composite score | r = 0.486 p < 0.001 n = 102 | r = 0.328 p = 0.014 n = 55 | r = 0.181 p = 0.225 n = 47 |
r, Pearson correlation coefficient; Rho, non-parametric correlation coefficient. DNMT1 or DNMT3A mRNAs were not significantly correlated with odor discrimination scores. (lg) is log10 transformation of variable which provided a more normal distribution of values.