Table 3.

Factors associated with frailty status among people with HIV in clinical care at 7 sites across the US in 2016-2019 in adjusted analyses by frailty category

	Prefrail vs. Not frail				Frail vs. Prefrail				Frail vs. Not frail
	RR	[95% Conf. Interval]		p-val	RR	[95% Conf. Interval]		p-val	RR	[95% Conf. Interval]		p-val
Female	1.25	1.16	1.35	<0.001	1.31	1.11	1.56	0.002	1.67	1.43	1.96	<0.001
Age (per decade)	1.05	1.03	1.07	<0.001	1.21	1.16	1.27	<0.001	1.30	1.25	1.36	<0.001
Race/ethnicity
White (ref)
Black	0.96	0.91	1.01	0.13	0.94	0.82	1.07	0.33	0.91	0.80	1.03	0.13
Hispanic	0.96	0.90	1.02	0.21	1.13	0.98	1.30	0.11	1.03	0.89	1.18	0.73
Other	0.99	0.90	1.10	0.91	1.13	0.92	1.40	0.25	1.11	0.90	1.36	0.34
MSM	1.02	0.95	1.09	0.57	1.01	0.87	1.18	0.88	1.00	0.87	1.16	0.95
Methamphetamine
Never (ref)
Former	1.03	0.97	1.10	0.30	1.10	0.95	1.28	0.21	1.12	0.97	1.30	0.13
Current	1.08	1.00	1.16	0.04	1.21	1.03	1.43	0.02	1.26	1.07	1.48	0.005
Cocaine/crack
Never (ref)
Former	1.04	0.97	1.10	0.26	1.09	0.95	1.26	0.22	1.17	1.01	1.35	0.04
Current	1.08	0.99	1.17	0.07	0.97	0.80	1.18	0.80	1.13	0.93	1.36	0.21
Marijuana
Never (ref)
Former	1.09	1.02	1.17	0.01	0.88	0.75	1.04	0.13	1.01	0.86	1.19	0.88
Current	1.11	1.03	1.19	0.005	0.98	0.83	1.16	0.82	1.16	0.98	1.37	0.09
Illicit Opioid
Never (ref)
Former	1.05	0.99	1.11	0.11	1.10	0.97	1.25	0.12	1.21	1.06	1.36	0.003
Current	1.18	1.08	1.29	<0.001	1.29	1.07	1.56	0.009	1.65	1.39	1.97	<0.001
Cigarette
Never (ref)
Former	1.08	1.02	1.15	0.01	1.04	0.90	1.20	0.59	1.16	1.00	1.34	0.053
Current	1.18	1.12	1.25	<0.001	1.26	1.10	1.44	0.001	1.61	1.41	1.85	<0.001
Alcohol
Non-drinker (ref)
Non-drinker, prior AUD	1.04	0.94	1.15	0.47	0.97	0.77	1.22	0.79	1.02	0.83	1.26	0.85
Non-hazardous	0.91	0.86	0.96	0.001	0.90	0.79	1.02	0.09	0.78	0.69	0.88	<0.001
Hazardous	0.87	0.81	0.93	<0.001	0.80	0.69	0.93	0.004	0.65	0.56	0.75	<0.001

In addition to above variables, also adjusted for PRO year

AUD: Alcohol use disorder; MSM: men who have sex with men

Not frail: 0 components; Prefrail: 1-2 components; Frail: 3-4 components