Table 4.
Factors associated with frailty status among people with HIV in clinical care at 7 sites across the US in 2016-2019 in adjusted analyses by frailty category using a frailty definition with a more conservative definition of prefrailty*
| Prefrail vs. Not frail | Frail vs. Prefrail | Frail vs. Not frail | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| RR | [95% Conf. Interval] |
p-val | RR | [95% Conf. Interval] |
p-val | RR | [95% Conf. Interval] |
p-val | ||||
| Female | 1.39 | 1.19 | 1.62 | <0.001 | 1.15 | 0.99 | 1.33 | 0.07 | 1.64 | 1.38 | 1.94 | <0.001 |
| Age (per decade) | 1.14 | 1.09 | 1.18 | <0.001 | 1.11 | 1.06 | 1.15 | <0.001 | 1.32 | 1.26 | 1.38 | <0.001 |
| Race/ethnicity | ||||||||||||
| White (ref) | ||||||||||||
| Black | 0.92 | 0.82 | 1.03 | 0.17 | 0.99 | 0.89 | 1.11 | 0.87 | 0.89 | 0.78 | 1.02 | 0.11 |
| Hispanic | 0.99 | 0.86 | 1.13 | 0.87 | 1.07 | 0.94 | 1.21 | 0.30 | 1.09 | 0.94 | 1.27 | 0.27 |
| Other | 0.94 | 0.76 | 1.16 | 0.57 | 1.14 | 0.96 | 1.37 | 0.14 | 1.11 | 0.89 | 1.38 | 0.37 |
| MSM | 0.96 | 0.84 | 1.09 | 0.50 | 1.04 | 0.91 | 1.18 | 0.57 | 0.99 | 0.85 | 1.15 | 0.90 |
| Methamphetamine | ||||||||||||
| Never (ref) | ||||||||||||
| Former | 0.99 | 0.87 | 1.14 | 0.91 | 1.09 | 0.97 | 1.24 | 0.15 | 1.11 | 0.94 | 1.30 | 0.22 |
| Current | 1.04 | 0.89 | 1.21 | 0.60 | 1.16 | 1.01 | 1.33 | 0.03 | 1.27 | 1.06 | 1.51 | 0.008 |
| Cocaine/crack | ||||||||||||
| Never (ref) | ||||||||||||
| Former | 1.08 | 0.94 | 1.23 | 0.28 | 1.05 | 0.93 | 1.18 | 0.44 | 1.17 | 1.00 | 1.36 | 0.054 |
| Current | 1.23 | 1.04 | 1.46 | 0.02 | 0.91 | 0.77 | 1.08 | 0.29 | 1.11 | 0.90 | 1.36 | 0.32 |
| Marijuana | ||||||||||||
| Never (ref) | ||||||||||||
| Former | 1.15 | 0.99 | 1.33 | 0.07 | 0.89 | 0.77 | 1.02 | 0.09 | 0.97 | 0.81 | 1.15 | 0.71 |
| Current | 1.20 | 1.03 | 1.40 | 0.02 | 0.94 | 0.82 | 1.09 | 0.42 | 1.12 | 0.94 | 1.34 | 0.21 |
| Illicit Opioid | ||||||||||||
| Never (ref) | ||||||||||||
| Former | 1.20 | 1.07 | 1.35 | 0.001 | 1.00 | 0.90 | 1.12 | 0.94 | 1.23 | 1.08 | 1.40 | 0.002 |
| Current | 1.41 | 1.17 | 1.69 | <0.001 | 1.11 | 0.94 | 1.31 | 0.21 | 1.61 | 1.33 | 1.96 | <0.001 |
| Cigarette | ||||||||||||
| Never (ref) | ||||||||||||
| Former | 1.12 | 0.98 | 1.27 | 0.09 | 1.00 | 0.89 | 1.14 | 0.95 | 1.14 | 0.97 | 1.32 | 0.11 |
| Current | 1.36 | 1.20 | 1.53 | <0.001 | 1.09 | 0.98 | 1.23 | 0.12 | 1.56 | 1.35 | 1.80 | <0.001 |
| Alcohol | ||||||||||||
| Non-drinker (ref) | ||||||||||||
| Non-drinker, prior AUD | 0.98 | 0.79 | 1.21 | 0.85 | 1.02 | 0.84 | 1.23 | 0.85 | 0.95 | 0.75 | 1.20 | 0.65 |
| Non-hazardous | 0.85 | 0.75 | 0.95 | 0.005 | 0.96 | 0.87 | 1.07 | 0.50 | 0.78 | 0.69 | 0.89 | <0.001 |
| Hazardous | 0.77 | 0.67 | 0.89 | <0.001 | 0.91 | 0.80 | 1.03 | 0.14 | 0.66 | 0.56 | 0.77 | <0.001 |
In addition to above variables, also adjusted for PRO year
AUD: Alcohol use disorder; MSM: men who have sex with men
Not frail: 0-1 components; Prefrail: 2 components; Frail: 3-4 components