Figure 2.

Neutralization of IL-17A significantly reduced infarct size and mortality. (A) Representative ADC weighted MRI images of mice treated with anti-IL-17A or IgG control (scale bar 5 mm). (B) Infarct volumes of both treatment groups from all centres (pooled data). Infarct volumes were analysed three days following tMCAO by MRI. The infarct volumes of rater one are shown in mm³. Graphs show mean ± SD. Statistical significance was assessed by linear-mixed model analysis (F(1,209) = 6.56, P = 0.01, n = 109). (C, D) Survival rate and number of dead mice. Statistical significance was assessed by a log-rank test (χ²₍₁₎ = 4.15, P = 0.04, n = 123).