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. 2023 Mar 17;5(2):fcad072. doi: 10.1093/braincomms/fcad072

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© The Author(s) 2023. Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Relationships between Nurr1 expression and CD8+ lymphocyte density. (A) Representative labelling of CD8+ cells using DAB immunostaining. (B) A negative correlation between Nurr1 expression and CD8+ lymphocytes is restricted to infragranular layers in multiple sclerosis cohort (Spearman rank-correlation coefficients). (C) Further assessment shows a significant increase in CD8+ lymphocytes in the cases lying at the lowest extreme of Nurr1 expression (n = 20) compared with the cases with the highest extreme of Nurr1 expression throughout all cortical layers (Mann-Whitney tests). *P < 0.05; scale bar 100 μm.