Table 1.
Demographics of multiple sclerosis and control cohort
| Multiple sclerosis cases (n = 46) | Controls (n = 11) | |
|---|---|---|
| Age of death (y) | 63 (range 40–92) | 76 (range 68–91) |
| Duration of disease (y) | 31 (range 11–58) | n/a |
| Sex | M = 12 F = 34 | M = 7 F = 4 |
| Clinical course | Primary progressive multiple sclerosis = 4; secondary progressive multiple sclerosis = 37; relapsing–remitting multiple sclerosis = 1; unknown = 4 | n/a |
| Brain weight (g) | 1159 (range 894–1380) | 1330 (range 1072–1628) |
| Time to wheelchair (y) | 19 (range 3–50) | n/a |
| PM interval (h) | 18 (range 7–38) | 28 (range 10–52) |
| Multiple sclerosis cohort at extremes of supragranular Nurr1 expression (GAD+ neurons and CD8+ inflammation assessment) | ||
| Multiple sclerosis: low Nurr1 (n = 10) | Multiple sclerosis: high Nurr1 (n = 10) | |
| Age of death (y) | 63 (range 46–77) | 63 (range 43–80) |
| Duration of disease (y) | 27 (range 19–39) | 31 (range 11–58) |
| Sex | M = 3 F = 7 | M = 3 F = 7 |
| Clinical course | Primary progressive multiple sclerosis = 1; secondary progressive multiple sclerosis = 9 | Primary progressive multiple sclerosis = 1; secondary progressive multiple sclerosis = 9 |
| Brain weight (g) | 1209 (range 1050–1380) | 1151 (range 1045–1291) |
| Time to wheelchair (y) | 20,5 (range 6–35) | 19,6 (range 4–50) |
| PM interval (h) | 17,7 (range 10–27) | 22,5 (range 13–28) |
n/a = not applicable; M = male; F = female; PM = post-mortem. Data on time to wheelchair was only available in 38 of the 46 cases studied.