Figure 2.

Mechanisms of action (white background boxes) and clinical outcomes (colored background boxes) with tirzepatide in SURPASS program. *Transient effect, MACE-4 (cardiovascular death, myocardial infarction, stroke, and hospitalisation for unstable angina), composite kidney outcome: time to first occurrence of estimated glomerular filtration rate (eGFR) decline of at least 40% from baseline, end-stage kidney disease, death due to kidney failure, or new-onset macroalbuminuria. VAT, visceral adipose tissue; ASAT, abdominal subcutaneous adipose tissue; WL, weight loss; T2DM, type 2 diabetes mellitus; HbA1c, glycosylated hemoglobin; TIR, time in range; MACE-4, major adverse cardiovascular event; HR, hazard ratio; CVD, cardiovascular disease; ACR, albumin-creatinine ratio.