Table 3.
Diagnostic performance of the subspecialists for different clinical endpoints.
| Subspecialists | Sensitivity | Specificity | PPV | NPV |
|---|---|---|---|---|
| (%; n/N) 95% CI |
(%; n/N) 95% CI |
(%; n/N) 95% CI |
(%; n/N) 95% CI |
|
| CIN2+ | ||||
| Senior colposcopist | 91.3 (94/103) | 46.8 (123/263) | 40.2 (94/234) | 93.2 (123/132) |
| 84.2–95.3 | 40.8–52.8 | 34.1–46.6 | 87.6–96.4 | |
| CAIADS | 80.6 (83/103) | 63.5 (167/263) | 46.4 (83/179) | 89.3 (167/187) |
| 71.9–87.1 | 63.0–71.4 | 39.2–53.7 | 84.1–93.0 | |
| Junior colposcopist | 79.6 (82/103) | 48.7 (128/263) | 37.8 (82/217) | 85.9 (128/149) |
| 70.8–86.3 | 42.7–54.7 | 31.6–44.4 | 79.4–90.6 | |
| CAIADS-Junior | 95.1 (98/103) | 48.3 (127/263) | 41.9 (98/234) | 96.2 (127/132) |
| 89.1–97.9 | 42.3–54.3 | 35.7–48.3 | 91.4–98.37 | |
| CIN3+ | ||||
| Senior colposcopist | 90.0 (63/70) | 42.2 (125/296) | 26.9 (63/234) | 94.7 (125/132) |
| 80.7–95.1 | 36.7–47.9 | 21.7–33.0 | 89.5–97.4 | |
| CAIADS | 80.0 (56/70) | 58.4 (173/296) | 31.3 (56/179) | 92.5 (173/187) |
| 69.2–87.7 | 52.8–63.9 | 25.0–38.4 | 87.8–95.5 | |
| Junior colposcopist | 85.7 (60/70) | 47.0 (139/296) | 27.6 (60/217) | 93.3 (139/149) |
| 75.7–92.1 | 41.4–52.7 | 22.1–34.0 | 88.1–96.3 | |
| CAIADS-Junior | 97.1 (68/70) | 43.9 (130/296) | 29.1 (68/234) | 98.5 (130/132) |
| 90.2–99.2 | 38.4–49.6 | 23.2–35.2 | 94.6–99.6 | |
| Cancer | ||||
| Senior colposcopist | 91.7 (22/24) | 38.0 (130/342) | 9.4 (22/234) | 98.5 (130/132) |
| 74.2–97.7 | 33.0–43.3 | 6.3–13.8 | 94.6–99.6 | |
| CAIADS | 100 (24/24) | 54.7 (187/342) | 13.4 (24/179) | 100.0 (187/187) |
| 86.2–100.0 | 49.4–59.9 | 9.2–19.2 | 97.99–100 | |
| Junior colposcopist | 87.5 (21/24) | 42.7 (146/342) | 9.7 (21/217) | 98.0 (146/149) |
| 69.0–95.7 | 37.6–48.0 | 6.4–14.3 | 94.25–99.31 | |
| CAIADS-Junior | 95.8 (23/24) | 38.3 (131/342) | 9.8 (23/234) | 99.2 (131/132) |
| 79.8–99.3 | 33.3–43.6 | 6.6–14.3 | 95.8–99.9 |
CAIADS, Colposcopic Artificial Intelligence Auxiliary Diagnostic System; CAIADS-Junior, CAIADS-assisted junior colposcopist; NPV, negative predictive value; PPV, positive predictive value; CIN, cervical intraepithelial neoplasia; 95% CI, 95% confidence interval; CIN2+, CIN grade 2 or worse; CIN3+, CIN grade 3 or worse; CI: confidence interval.