FIGURE 1.

APN protects skeletal muscle from IR injury by reducing oxidative stress and inhibiting inflammatory response, apoptosis and autophagy; A, APN injection could effectively increase the APN level of plasma in IR mice; B, APN injection could effectively increase the APN level of gastrocnemius in IR mice; C, APN injection significantly ameliorated the IR‐induced increase in CK and oxidative stress levels in mouse plasma; D, APN injection significantly ameliorated the IR‐induced increase in inflammatory factor levels in the gastrocnemius of mice; **P < 0.01 versus sham, ##P < 0.01 versus sham + APN, &&P < 0.001 versus IR