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. 2022 Nov 25;20(5):1647–1661. doi: 10.1111/iwj.14022

FIGURE 6.

FIGURE 6

MiR‐21 protects gastrocnemius by inhibiting IR‐induced apoptosis and autophagy through PI3K; A, MiR‐21 inhibited IR‐induced gastrocnemius apoptosis through PI3K in mice; B, MiR‐21 inhibited the expression of apoptosis‐related proteins induced by IR in gastrocnemius through PI3K; C, MiR‐21 inhibited the expression of autophagy marker proteins induced by IR in gastrocnemius through PI3K; D, MiR‐21 promoted the expression of downstream target genes in gastrocnemius of IR mice through PI3K; *P < 0.05 and **P < 0.01 versus IR + miR‐NC, #P < 0.05 and ##P < 0.01 versus IR + miR‐21 mimic; bar = 100 μm