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. 2023 Mar 27;14(5):784–792. doi: 10.7150/jca.78423

Figure 5.

Figure 5

DEPDC1B promotes the proliferation of EOC cells by enhancing AKT phosphorylation. (A) Colony formation assay shows reduction in the number of colonies on treatment with MK-2206 and LY294002 in DEPDC1BOE and DEPDC1BCtrl OVCAR3 and SKOV3 cells. (B) EdU cell proliferation assay shows reduction in cell proliferation on treatment with MK-2206 and LY294002 in DEPDC1BOE and DEPDC1BCtrl OVCAR3 and SKOV3 cells. Data shown are the mean ± SEM of three independent experiments. **, P < 0.01, #, P > 0.05. (C) Protein levels of c-Myc in DEPDC1BOE and DEPDC1BCtrl OVCAR3 and SKOV3 cells were determined by western blot assays. (D) Western blot showing a reduction in c-Myc expression on treatment with LY294002 in DEPDC1BOE and DEPDC1BCtrl OVCAR3 and SKOV3 cells. (E) Western blot showing a reduction in c-Myc expression on treatment with MK2206 in DEPDC1BOE and DEPDC1BCtrl OVCAR3 and SKOV3 cells.