Table 2.
Regression β coefficients from univariable and multivariable analyses for overall survival
| Univariable analysis | Multivariable analysis | ||||||
|---|---|---|---|---|---|---|---|
| Variables | Regression β coefficient | Crude HR (95% CI) | P-value | Regression β coefficient | Adjusted HR (95% CI) | P-value | |
| NLR ≥4.2 | 0.939 | 2.56 (1.68-3.90) | <0.001 | 0.865 | 2.38 (1.50-3.77) | <0.001 | |
| PPIs | 0.597 | 1.82 (1.21-2.73) | 0.004 | 0.318 | 1.38 (0.86-2.19) | 0.181 | |
| NSAIDs | 0.452 | 1.57 (1.04-2.37) | 0.032 | 0.125 | 1.13 (0.69-1.86) | 0.622 | |
| Corticosteroids | 0.211 | 1.23 (0.45-3.37) | 0.681 | 0.110 | 1.12 (0.34-3.68) | 0.856 | |
| Age (10-year interval) | 0.120 | 1.13 (0.90-1.41) | 0.293 | 0.069 | 1.01 (0.98-1.38) | 0.586 | |
| ECOG PS ≥2 | 1.926 | 6.86 (3.92-12.01) | <0.001 | 1.683 | 5.38 (2.95-9.82) | <0.001 | |
Ten patients with unknown ECOG PS were excluded from this analysis.
Abbreviations: HR: hazard ratio; CI: confidence interval; NLR: neutrophil-to-lymphocyte ratio; PPIs: proton pump inhibitors; NSAIDs: non-steroidal anti-inflammatory drugs; ECOG PS: Eastern Cooperative Oncology Group performance status.