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. 2023 Apr 10;55(1):2189295. doi: 10.1080/07853890.2023.2189295

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© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 6. — GC with GPC3^high CAFs is insensitive to PD-1 blockage therapy in vivo. (A) The mice fibroblasts (L929 cells) after GPC3 overexpression lentivirus transfection. (B) The mice xenograft model construction and divide into four groups. (C) Tumour volume comparison after different treatment in the mice GC xenograft model. (D) Immunofluorescence were used to detect the GPC3 positive CAFs in xenograft tumour tissue. (E,F) The proportion of interferon (IFN)-γ-positive cells of CD8+ T cells in the tumours of different groups (*p < .05; **p < .01, ***p < .001).