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. 2023 Apr 10;55(1):2189295. doi: 10.1080/07853890.2023.2189295

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© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 7. — Targeting GPC3 sensitizing the PD-1 blockage therapy in GC. (A) ELISA was used to detect the culture medium after GPC3 overexpression in mice fibroblasts. (B) The co-culture model to study the impact fibroblasts with GPC3 overexpression of to HGC-27 cells. (C) rt-qPCR was used to detect the immune checkpoints expression after co-culture with fibroblasts, the immune checkpoint genes included PD-L1, TIM3, CD24, CYCLIN D1, cMYC and PDK. (D) The immune checkpoint genes expression of HGC-27 cells under the anti-GPC3 treatment. (E) The mice xenograft model construction and divide into four groups. (F) Tumour volume comparison after different treatment in the mice GC xenograft model. (G,H) The proportion of interferon (IFN)-γ-positive cells of CD8+ T cells in the tumours of different groups (*p < .05; **p < .01, ***p < .001).