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. 2022 Dec 12;192(4):600–611. doi: 10.1093/aje/kwac202

Table 3.

Results of Applying the 3 Strategies to Data Generated Under Different Scenarios, With Inline graphic and Inline graphic

Strategy Inline graphic a Inline graphic Bias Coverage RMSE MCE
No Missingness
1 0 0 0.00 95.0 0.00 0.01
MCAR
1 0 0 0.01 95.0 0.24 0.01
2 0.01 94.6 0.14 0.00
3 0.00 97.9 0.22 0.01
MAR
1 −0.4 0 −0.09 93.2 0.26 0.01
2 −0.07 91.7 0.17 0.00
3 −0.01 97.9 0.24 0.01
1 0.4 0 0.05 94.3 0.22 0.01
2 0.07 92.8 0.14 0.00
3 0.00 97.6 0.22 0.01
MNAR
1 0.4 0.4 0.16 86.3 0.26 0.01
2 0.17 73.0 0.22 0.00
3 −0.00 97.3 0.20 0.01
1 0.2 0.2 0.12 90.4 0.24 0.01
2 0.12 85.3 0.17 0.00
3 0.00 97.6 0.22 0.01
1 −0.2 −0.2 −0.17 90.0 0.30 0.01
2 −0.15 83.3 0.22 0.00
3 0.00 98.2 0.07 0.01
1 −0.4 −0.4 −0.33 75.3 0.42 0.01
2 −0.31 53.4 0.34 0.01
3 0.01 98.7 0.17 0.01

Abbreviations: MAR, missing at random; MCAR, missing completely at random; MCE, Monte Carlo error; MNAR, missing not at random; RMSE, root mean square error; Inline graphic, target trial emulated from observed data; TTtrue, the full eligibility target trial, containing all those who are eligible.

a Average size of Inline graphic for the 7 settings of Inline graphic and Inline graphic are n = 250, 228, 271, 328, 294, 206, and 172 respectively. Average size of Inline graphic is 500. Note that the average causal effect Inline graphic was calculated from a single simulation with Inline graphic and was estimated at 2.386.