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. 2023 Mar 9;120(11):e2217891120. doi: 10.1073/pnas.2217891120

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Copyright © 2023 the Author(s). Published by PNAS.

This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 4. — Effects of p.S396D on ABR and DPOAE thresholds. (A) A bound chloride and p.S396D (modeled by PyMOL) within the human prestin structure (PDB ID: 7LGU) are indicated by red spheres. ABR (B) and DPOAE (C) threshold shifts (compared to WT) for S396D-prestin and R130S/S396D-prestin homozygous mice determined between P29 and 43. Short horizontal solid lines indicate means and propagated errors calculated from SDs of the threshold data. A dashed horizontal line at 0 dB SPL is provided for reference and signifies no change in sensitivity between mutant and control. “*”, 0.01 ≤ P < 0.05.