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. 2023 Apr 12;43(15):2665–2681. doi: 10.1523/JNEUROSCI.1365-22.2023

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Figure 5. — M335A increases the sodium sensitivity of Slack channel mutants. A, Sample current traces recorded in the inside-out patch configuration for Y375A. The ramp protocol ran from −100 to +100 mV. B, Sample current traces recorded in the inside-out patch configuration for the Y375A/M335A mutant with a ramp protocol ran from −100 to +100 mV. C, Hill equation fits the Na⁺ dose dependence data of Y375A and Y375A/M335A mutants. D, Comparison of EC₅₀ values of the sodium dependence of L371A to Y375A with the EC₅₀ values of the sodium dependence of double mutants of M335A plus corresponding mutants from L371A to Y375A. E, Hill equation fits the Na⁺ dose dependence data of M335A/D955N and M335A/E491Q. F, Comparison of minimum EC₅₀ values of sodium dependence of E490Q, E491Q, E787Q, E899A, and D955N with the minimum EC₅₀ values of sodium dependence of M335A/E490Q, M335A/E491Q, M335A/E787Q, M335A/E899A, and M335A/D955N.