Table 3.
Characterization of EC50 of sodium dependence of the rSlack channel mutations
| Channels | EC50 or minimum EC50 (in mm) | Patch numbers |
|---|---|---|
| M335A | 49 ± 3 | 4 |
| M335A/E490Q | 1072 ± 36 | 6 |
| M335A/E491Q | 341 ± 21 | 6 |
| M335A/E787Q | 480 ± 34 | 6 |
| M335A/D863N | 1154 ± 17.5 | 7 |
| M335A/E865Q | 1430 ± 73.2 | 8 |
| M335A/E899A | 982 ± 56 | 6 |
| M335A/D955N | 331 ± 12 | 6 |
| M335A/D1196N | 82.6 ± 2.6 | 5 |
| L371A | 643 ± 21 | 6 |
| N372A | 369 ± 20 | 5 |
| F374A | 623 ± 30 | 5 |
| Y375A | 600 ± 34 | 6 |
| M335A/L371A | 204 ± 17 | 5 |
| M335A/N372A | 110 ± 10 | 5 |
| M335A/F374A | 359 ± 38 | 6 |
| M335A/Y375A | 297 ± 6 | 5 |