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. 2023 Mar 27;19(3):e1010678. doi: 10.1371/journal.pgen.1010678

Table 1. List of resistance associated transcripts commonly over-expressed between bendiocarb resistant (R), unexposed An. funestus (C) from Malawi and the FANG susceptible (S) strain at fold-change>2 (or 1.5 for R vs. C) FDR<0.05.

Gene ID R vs.S C vs.S R vs.C Description
AFUN019813 79.9 37.4 2.1 Retrovirus-related Pol polyprotein from transposon TNT 1–94
AFUN011266 3.6 2.2 1.7 UDP-glucuronosyltransferase 3A1
AFUN017296 7.0 4.4 1.6 microRNA mir-279
AFUN018674 6.1 3.6 1.7 Serine protease easter
AFUN011978 11.1 6.1 1.8 PiggyBac transposable element-derived protein 4
AFUN019220 3.8 3.1 ATP-binding cassette transporter (ABC transporter) family A member
AFUN019401 2.1 2.9 Cytochrome P450, CYP6M4
AFUN015785 2.2 2.1 Cytochrome P450, CYP6AA2
AFUN015801 2.5 2.3 Cytochrome P450, CYP6P2
AFUN020895 6.2 6.0 Cytochrome P450, CYP6P4a
AFUN001382 3.0 3.4 Cytochrome P450, CYP9J5
AFUN001383 4.0 4.1 Cytochrome P450, CYP9J5
AFUN015792 43.3 53.4 Cytochrome P450, CYP6P9a
AFUN015889 17.0 16.6 Cytochrome P450, CYP6P9b
AFUN002978 2.5 2.0 Cytochrome P450, CYP314A1
AFUN015807 2.6 2.6 Glutathione S-transferase, GSTe1
AFUN015839 3.6 5.1 Glutathione S-transferase, GSTD3
AFUN016008 3.2 2.8 Glutathione S-transferase, GSTe6
AFUN000622 2.2 3.0 solute carrier family 23 (nucleobase transporter)
AFUN021547 2.2 2.3 Sugar transporter SWEET
AFUN016449 3.1 3.8 Trypsin
AFUN020614 2.5 2.9 Trypsin
AFUN003724 2.5 3.1 CCAAT/enhancer-binding protein gamma
AFUN019110 2.7 3.2 Transcription factor Adf-1
AFUN008611 6.7 7.1 Transposon TX1 uncharacterized 149 kDa protein
AFUN020948 2.9 1.9 Chymotrypsin-1
AFUN015887 3.1 1.7 Gustatory receptor 68a
AFUN009199 2.6 1.5 Chitin synthase 6
AFUN007080 2.7 2.2 Caspase-1
AFUN021252 2.1 Zinc finger protein 91
AFUN008941 2.5 ATP-binding cassette transporter (ABC transporter) family C member
AFUN015776 2.1 Cytochrome P450 CYP12F1
AFUN007186 2.1 Facilitated trehalose transporter Tret1
AFUN006135 2.1 Cytochrome P450, CYP4C36
AFUN003300 2.2 Zinc finger protein 420
AFUN018998 2.0 Zinc finger protein 337
AFUN000799 2.2 Zinc finger CCHC-type and RNA-binding motif-containing protein 1
AFUN010918 2.2 Cytochrome P450, CYP6N1
AFUN014520 2.0 CCR4-NOT transcription complex subunit 7
AFUN021519 2.1 Zinc finger protein 84
AFUN021263 2.0 Transcription initiation factor TFIID subunit 8
AFUN016502 2.2 Sodium/potassium/calcium exchanger 5
AFUN020670 2.7 Xanthine dehydrogenase
AFUN015907 2.2 Cytochrome P450, CYP305A3
AFUN008943 1.7 ATP-binding cassette transporter (ABC transporter) family C member
AFUN021444 2.0 Zinc carboxypeptidase A 1