| 3.1 All‐cause mortality prior to hospital discharge |
3 |
333 |
Risk Difference (M‐H, Fixed, 95% CI) |
‐0.03 [‐0.10, 0.04] |
| 3.1.1 High‐loading and high‐maintenance dose versus standard‐loading and standard‐maintenance dose |
2 |
169 |
Risk Difference (M‐H, Fixed, 95% CI) |
‐0.02 [‐0.11, 0.07] |
| 3.1.2 Standard‐loading and high‐maintenance dose versus standard‐loading and standard‐maintenance dose |
1 |
164 |
Risk Difference (M‐H, Fixed, 95% CI) |
‐0.04 [‐0.13, 0.06] |
| 3.2 Failure to extubate within one week of commencing treatment |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 3.2.1 High‐loading and high‐maintenance dose versus standard‐loading and standard‐maintenance dose |
1 |
78 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.48 [0.24, 0.92] |
| 3.3 Side effects (tachycardia, agitation, or feed intolerance) leading to a reduction in dose or withholding of caffeine |
2 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 3.3.1 High‐loading and high‐maintenance dose versus standard‐loading and standard‐maintenance dose |
2 |
150 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.92 [0.53, 6.90] |
| 3.4 Bronchopulmonary dysplasia/chronic lung disease at 36 weeks' postmenstrual age |
3 |
333 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.72 [0.47, 1.11] |
| 3.4.1 High‐loading and high‐maintenance dose versus standard‐loading and standard‐maintenance dose |
2 |
169 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.75 [0.42, 1.35] |
| 3.4.2 Standard‐loading and high‐maintenance dose versus standard‐loading and standard‐maintenance dose |
1 |
164 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.68 [0.36, 1.29] |
| 3.5 Intraventricular hemorrhage, any grade |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 3.5.1 High‐loading and high‐maintenance dose versus standard‐loading and standard‐maintenance dose |
1 |
49 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.21 [0.03, 1.66] |
| 3.6 Intraventricular hemorrhage, grade 3 to 4 |
2 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 3.6.1 High‐loading and high‐maintenance dose versus standard‐loading and standard‐maintenance dose |
2 |
169 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.14 [0.46, 2.82] |
| 3.7 Periventricular leukomalacia |
1 |
120 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.25 [0.35, 4.43] |
| 3.7.1 High‐loading and high‐maintenance dose versus standar‐loading and standard‐maintenance dose |
1 |
120 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.25 [0.35, 4.43] |
| 3.8 Necrotizing enterocolitis (proven = Bell stage of 2 or greater) (Bell 1978) |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 3.8.1 High‐loading and high‐maintenance dose versus standard‐loading and standard‐maintenance dose |
1 |
120 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.67 [0.20, 2.24] |
| 3.9 Retinopathy of prematurity (ROP) (any ROP) (International Committee 2005) |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 3.9.1 High‐loading and high‐maintenance dose versus standard‐loading and standard‐maintenance dose |
1 |
49 |
Risk Ratio (M‐H, Fixed, 95% CI) |
4.17 [0.50, 34.66] |
| 3.10 Retinopathy of prematurity (ROP) (severe ROP [stage 3 or greater]) (International Committee 2005) |
2 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 3.10.1 High‐loading and high‐maintenance dose versus standard‐loading and standard‐maintenance dose |
2 |
169 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.85 [0.29, 2.54] |
