Study	Reason for exclusion
Autret 1985	Infants were randomized to two caffeine doses which both fall within the "standard dose" definition used in this review. Loading and maintenance dose were 20 mg/kg and 5 mg/kg caffeine in group one, respectively; 20 mg/kg and 3 mg/kg in group two, respectively.
Cherif 2003	Not an RCT
Gray 2016	Not an RCT
Romagnoli 1992	Infants were randomized to two caffeine doses which both fall within the "standard dose" definition used in this review. Loading and maintenance dose were 10 mg/kg and 5 mg/kg caffeine in group one, respectively; 10 mg/kg and 2.5 mg/kg in group two, respectively.
Wan 2020	Infants were randomized to two caffeine doses which both fall within the "standard dose" definition used in this review. Loading and maintenance dose were 20 mg/kg and 10 mg/kg caffeine in group one, respectively; 20 mg/kg and 5 mg/kg in group two, respectively.
Yao 2021	Infants were randomized to two caffeine doses which both fall within the "standard dose" definition used in this review. Loading and maintenance dose were 20 mg/kg and 5 mg/kg caffeine in both group one and group two, whereas group one received am additional dose caffeine one hour before ventilator weaning.
Zhang 2019	Infants were randomized to two caffeine doses which both fall within the "standard dose" definition used in this review. Loading and maintenance dose were 20 mg/kg and 10 mg/kg caffeine in group one, respectively; 20 mg/kg and 5 mg/kg in group two, respectively.