Gray 2018.

Methods	Conference abstract with no full text; unclear if randomized.
Participants	Infants < 28 weeks’ gestation who received a loading dose of caffeine within the first 36 hours of life from 2011 to 2013 were included in the study.
Interventions	High‐dose group: median dose of 80 mg/kg Standard‐dose group: median dose of 20 mg/kg
Outcomes	Neonatal outcomes including results of cranial ultrasound were compared. The infants were followed up at 2 years of age and had a neurological assessment, the Bayley Scales of Infant and Toddler Development, 3rd Edition and the Neurosensory Motor Developmental Assessment (NSDMA) The incidence of cerebellar hemorrhage was 4 (2.5%) in the high‐dose group and 1 (1.7%) in the standard‐dose group, with no difference in the incidence of IVH. The mean cognitive score on the Bayley for the high‐dose group was 97.4 compared with 91.9 for the standard‐dose group (P = 0.06). There were no differences in the language or motor scores, the NSMDA results, or the incidence of cerebral palsy between the groups.
Notes

IVH: intraventricular hemorrhage; kg: kilogram; mg: milligram