Table 2.
Factors associated with the risk of advanced TNM stage III/IV or metastasis
| Group (vs. reference) | No. of CRC cases | Multivariate OR (95% CI)1 | |
|---|---|---|---|
| Stage III/IV | Metastasis | ||
| Pandemic period (vs. pre-pandemic) | 1,430/928 | 0.768 (0.647, 0.911) | 0.926 (0.742, 1.156) |
| Male (vs. female) | 1,447/911 | 1.008 (0.811, 1.253) | 1.244 (0.939, 1.648) |
| Age <65 yr (vs. ≥65 yr) | 1,024/1,334 | 1.240 (1.042, 1.476) | 1.338 (1.068, 1.675) |
| Symptomatic diagnosis (vs. screening) | 1,490/868 | 2.496 (2.093, 2.978) | 3.064 (2.344, 4.006) |
| Family history of CRC (vs. no) | 165/2,193 | 0.825 (0.594, 1.148) | 0.878 (0.567, 1.361) |
| Rural residency (vs. urban) | 666/1,692 | 1.093 (0.908, 1.317) | 0.924 (0.723, 1.180) |
| Diabetes (vs. no) | 600/1,758 | 1.005 (0.828, 1.220) | 0.941 (0.727, 1.216) |
| Smoker (vs. never smoker) | 981/1,377 | 0.997 (0.802, 1.239) | 0.962 (0.729, 1.270) |
| Alcohol drinking (vs. never drinker) | 1,486/872 | 1.219 (1.007, 1.476) | 1.169 (0.912, 1.498) |
| BMI <25 kg/m2 (vs. ≥25 kg/m2) | 1,631/727 | 1.253 (1.043, 1.505) | 1.541 (1.192, 1.992) |
CRC, colorectal cancer; OR, odds ratio; CI, confidence interval; BMI, body mass index
1
ORs were calculated by logistic regression.